pleasure and pain study shows brains pleasure chemical is involved in response to pain too date october 19, 2006 source university of michigan health system. From a stimulus-response perspective, the perception of physical pain starts with the nociceptors, a type of physiological receptor that transmits neural signals to the brain when activated. These receptors are commonly found in the skin, membranes, deep fascias, mucosa, connective tissues of visceral organs, ligaments and articular capsules, muscles. The reward system contains pleasure centers or hedonic hotspots i. , brain structures that mediate pleasure or liking reactions from intrinsic rewards. As of october 2017, update hedonic hotspots have been identified in subcompartments within the nucleus accumbens shell , ventral pallidum , parabrachial nucleus , orbitofrontal cortex (ofc), and insular cortex. Pleasure and pain study shows brains pleasure chemical is involved in response to pain too. Journal journal of neuroscience funder national institutes of. Pleasure and pain study shows brains pleasure chemical is involved in response to pain too for years, the brain chemical dopamine has been thought of as the brains pleasure chemical, sending signals between brain cells in a way that rewards a person or animal for one activity or another.